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In Cuenca, you'll find the Zona Rosa along Calle Larga, within easy walking distance of the historic center.
Most of the bars and discotecas in the pueblos, such as Banos and Montanita, are centrally located.
This is then presented to the bar staff instead of paying with cash.
Every Ecuadorian city features a Zona Rosa, or main nightlife district, where you'll find the highest density of bars, discotecas (clubs), and restaurants. In Guayaquil, there are a few places, with Las Penas being the safest and most easily accessible.
Just follow the music, and you should have no trouble finding the action.
Nightlife in Ecuador is pretty quiet Sunday through Wednesday unless you know the right places to go to (hint: ask the locals).
If you get to a club early, don't be surprised if you just see everyone sitting around. As a result of the group dynamic, it can be hard for travelers to meet Ecuadorians at bars and clubs.
The best approach is to be friendly and straightforward.